These trials completed more than 12 months ago and should have reported results. Some have, some have not.

These trials are not yet due to report results: some are ongoing, some completed within the past 12 months.

These trials have problematic data on the registry. Details why »

Status Trial ID Title Completion date Category
Listed as ongoing, but also has a completion date 2004-000242-20 A randomised trial of the European and American Osteosarcoma Study group to optimize treatment strategies for resectable osteosarcoma based on histological response to pre-operative chemotherapy 2013-06-17 bad-data
Completed, but no date 2004-001113-33 Effect of TNFalpha blockade on the induction of specific B cell responses in vivo, using human spondyloarthropathy as model. bad-data
Completed, but no date 2004-001126-24 Feasibility of radiotherapy and concomitant gemcitabine and oxaliplatin in locally advanced pancreatic cancer and distal cholangiocarcinoma bad-data
Ongoing 2004-001285-40 Wat is de ideale concentratie van Ropivacaine bij Sufenta 0,75 microgram/ml voor Thoracale Epidurale? not-yet-due
Completed, but no date 2004-002311-91 A randomised, controlled, 4-week, cross-over study assessing the efficacy and safety of adding oral morphine IR 10mg or sublingual buprenorphine 0.2mg on demand to a treatment with transdermal bupreno... bad-data
Completed, but no date 2005-000596-17 Dubbel blind gerandomiseerde studie waar metformine versus placebo toegediend worden in de behandeling van NASH bij patiënten die omwille van obesitas bariatrische chirurgie ondergaan. bad-data
Completed, but no date 2005-001797-27 Accuracy of the Kataria model for propofol anesthesia in children bad-data
Ongoing 2005-003956-37 Five year single blind, phase III effectiveness randomised actively controlled clinical trial in new onset juvenile dermatomyositis: prednisolone versus prednisone plus cyclosporine A versus prednison... not-yet-due
Listed as ongoing, but also has a completion date 2005-003957-28 FIVE-YEAR SINGLE-BLIND, PHASE II EFFECTIVENESS RANDOMISED ACTIVELY CONTROLLED CLINICAL TRIAL IN NEW ONSET JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS NEPHTRITIS ORAL CYCLOPHOSPHAMIDE VERSUS HIGH DOSE INTRA... 2007-06-25 bad-data
Ongoing 2005-004420-39 An Open Label Phase II Multicentre Clinical Trial of Single Agent VELCADE (Bortezomib) in Patients with Malignant Pleural Mesothelioma not-yet-due
Completed, but no date 2005-004632-40 Study on the pharmacodynamic interactions between propofol and sevoflurane during induction of anesthesia. bad-data
Completed, but no date 2005-005428-15 Vergelijkende studie tussen Propofol en Sevoflurane: sedatie en hemodynamiek postoperatief na electieve CABG (Coronair bypass chirurgie) bad-data
Completed, but no date 2005-005474-77 Validation of a pharmacologic profile of propofol bad-data
Ongoing 2005-005733-35 Invloed van corticoïden op de nierfunctie postoperatief na cardiochirurgie not-yet-due
Completed, but no date 2005-005739-91 Functional Neuroimaging in depression: longitudinal study of PET metabolism in correlation with changes in attentional bias, autobiographical memory, future fluency and facial recognition in depressed... bad-data
Completed, but no date 2006-000179-13 Validation of the methodology of serum creatinine measurement and the estimated glomular filtration ratio bad-data
Not reported 2006-000460-90 Echocardiographic study of the haemodynamic effects of remifentanil with and without glycopyrrolate in healthy children 2009-04-06 due-trials
Completed, but no date 2006-000744-17 A randomised phase II study evaluating two schedules of the 21-day regimen of Gemcitabine and Carboplatin in advanced NSCLC bad-data
Completed, but no date 2006-000925-71 TNF-blockade for the treatment of erosive osteoarthritis (OA) of interphalangeal finger joints. Randomized, double blind, placebo-controlled study to evaluate the efficacy of adalimumab 40 mg sc every... bad-data
Ongoing 2006-001150-27 Sandostatin LAR in prevention of Chemotherapy Induced Diarrhea not-yet-due
Completed, but no date 2006-002901-30 Tramadol iv. : influence of dose and dose intervals on therapeutic accuracy and side effects when used for postoperative pain relief in ambulatory surgery bad-data
Completed, but no date 2006-003524-11 Clinical and biological effects of Anti-IgE (Omalizumab) in patients with bilateral nasal polyposis and asthma bad-data
Ongoing 2006-003836-31 A protocol based treatment for early and severe systemic sclerosis with (anti-CD-20) rituximab not-yet-due
Not reported 2006-003991-37 Trial of beta blocker therapy (atenolol) vs. angiotensin II receptor blocker therapy (losartan) in individuals with Marfan syndrome 2013-02-13 due-trials
Completed, but no date 2006-005530-21 Comparison of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) with gadofosveset trisodium (Vasovist, Schering, Berlin, Germany) to gadopentetate dimeglumine (GD-DTPA, Magnevist, Scherin... bad-data
Not reported 2006-006334-18 Farmacokinetische evaluatie van de overschakeling van intraveneuze naar enterale toediening van moxifloxacine bij Intensieve Zorgen patiënten 2012-09-24 due-trials
Completed, but no date 2006-006727-39 A prospective randomised controlled trial on the use of BMP-7 (Bone Morphogenetic Protein-7) (OP-1®) and demineralised bone matrix (DBM) in tibial non-union. bad-data
Completed, but no date 2006-006965-18 Acute hemodynamische impact van een intraveneuze glucose injectie bad-data
Completed, but no date 2007-000099-17 Farmacokinetische evaluatie van enteraal toegediende omeprazole-suspensie bij patiënten met cerebral palsy. bad-data
Completed, but no date 2007-001858-70 Effect of inhaled tiotropium bromide on neurokinin-A induced bronchoconstriction in asthma. bad-data
Not reported 2007-002640-19 Effect of strategy for blood pressure control on cerebral oxygen balance during aortic coarctation repair: a randomized study 2012-03-15 due-trials
Completed, but no date 2007-002707-40 The effect of inhalation with hypertonic saline (7%) on lung function and sputum rheology in Cystic Fibrosis patients bad-data
Ongoing 2007-003151-36 Sevoflurane-Remifentanil interaction: Multiple response surfaces, validation of calibration stimuli, validation of the intraoperative isobole concept and investigating remifentanil induced opioid tole... not-yet-due
Ongoing 2007-003994-18 EHOA: Etanercept as treatment for Hand OsteoArthritis not-yet-due
Completed, but no date 2007-004737-42 Moviprep versus fleet phospho-soda (golden standard): een vergelijkende studie van laxativa als voorbereiding van de darm op een chirurgische ingreep bad-data
Completed, but no date 2007-005862-10 Randomized, double-blind study for the evaluation of the effect of losartan versus placebo on aortic root dilatation in patients with Marfan syndrome under treatment with beta-blockers. bad-data
Not reported 2007-006217-16 Evaluation of the accuracy, safety and robustness of a single-input-single output (SISO) model-based predictive closed-loop system to guide patient-individualized ICU sedation. 2009-09-08 due-trials
Completed, but no date 2007-006443-50 Prospective, randomized trial to evaluate the administration of 2 different doses of recombinant FSH to patients with age depended insufficient ovarian response during IVF/ICSI bad-data
Ongoing 2007-007019-10 Comparison of the therapeutic efficacy and side effects of tramadol per os (Tradonal Odis® orodispersible tablets) versus an optimised dosis of travenous tramadol for postoperative pain relief in ambu... not-yet-due
Ongoing 2007-007668-15 Evaluatie van Arthroscopisch Voorste Kruisband Herstel via Ziekenhuisopname of via Dagopname: een Gerandomiseerde Prospectieve Klinische Studie. not-yet-due
Not reported 2008-000769-49 Unicentrische vergelijkende studie van suctie curretage met standaard BOTOX injectie bij de behandeling van patiënten met essentiële axillaire hyperhidrosis: vergelijking van efficaciteit, duur van ef... 2011-08-22 due-trials
Ongoing 2008-001853-17 Invloed van behandeling met infliximab op immuuncellen in het bloed van patiënten met spondyloartritis not-yet-due
Ongoing 2008-002982-30 A Prospective, randomized, clinical study on the effects of CPP-ACP paste on plaque, gingivitis and initial caries lesion development in orthodontic patients - part 2 not-yet-due
Completed, but no date 2008-003484-39 Farmacokinetische evaluatie van de eerste intraveneuze dosering van quinolones bij Intensieve Zorgen (IZ) patiënten met septische shock. bad-data
Not reported 2008-003661-19 Invloed van laag gedoseerde hormonale substitutie op insulinespiegels bij postmenopausale vrouwen 2014-11-06 due-trials
Not reported 2008-004089-15 The AZISAST Randomized Controlled Clinical Trial: Azithromycine as add-on therapy in Severe, Non-Eosinophilic Asthma 2011-09-30 due-trials
Not reported 2008-004113-96 DRainage versus sEAlant in prospective, Monocentric, double blinded randomized trial to evaluate the effect of fibrin glue in surgical repair of incisional hernias (DREAM-trial) 2014-10-14 due-trials
Completed, report not yet due 2008-005224-91 Het gebruik van laag moleculair gewicht heparines (LMGH) tijdens hemodialyse. 2018-05-15 not-yet-due
Completed, but no date 2008-006825-15 Extended infusie van betalactam en carbapenem antibiotica: farmakokinetische aspecten in patienten met verschillende gradaties in nierfunctie. bad-data
Completed, but no date 2008-008317-20 The effect of inhaled N-Acetylcysteine compared to normal saline on sputum rheology and lung function bad-data
Completed, but no date 2008-008319-24 A single-center, randomized, double blind, placebo-controlled study to evaluate the efficacy and safety of Somatostatin used as inflow modulator in liver transplantation. bad-data
Completed, but no date 2009-011623-31 Individually adapted immunosuppression in de novo renal transplantation based on immune function monitoring: a prospective randomised study Extension study: The impact of magnesium supplementation on ... bad-data
Ongoing 2009-012034-70 A protocol based treatment for debilitating fibrosing skin disorders with (anti-CD-20), rituximab not-yet-due
Ongoing 2009-012981-30 Prospective study to assess the efficacy and safety of lanreotide 120 mg as treatment of clinical symptoms associated with inoperable intestinal obstruction not-yet-due
Listed as ongoing, but also has a completion date and reported results 2009-014037-25 Bortezomib (Velcade®): a feasibility and phase II study in childhood relapsed acute lymphoblastic leukemia 2015-10-21 bad-data
Listed as ongoing, but also has a completion date 2009-014293-17 Phase II study of cetuximab combined with cisplatin or carboplatin/pemetrexed as first line treatment in patients with malignant pleural mesothelioma. 2015-02-13 bad-data
Ongoing 2009-014462-26 Dutch-Belgian pediatric AML protocol for children with newly diagnosed acute myeloid leukemia, based on the NOPHO-AML 2004 study not-yet-due
Not reported 2009-015890-11 Conditioning with volatile anesthetics in liver transplantation 2012-07-18 due-trials
Completed, but no date 2009-016094-16 Sevoflurane-Remifentanil interaction: Multiple response surfaces, validation of calibration stimuli, validation of the intraoperative isobole concept and investigating remifentanil induced opioid tole... bad-data
Completed, but no date 2009-016785-88 Dexmedetomidine pharmacokinetics-pharmacodynamics in mechanically ventilated children with single-organ respiratory failure bad-data
Ongoing 2009-016857-16 Dose finding study for effective reversal of a moderate rocuronium-induced neuromuscular block with sugammadex in morbidly obese patients not-yet-due
Ongoing 2009-017265-33 Invloed van voeding op farmacokinetiek en -dynamiek van desmopressine tablet in vergelijking met desmopressine MELT-vorm not-yet-due
Ongoing 2009-017425-19 Vitiligo en het Koebnerfenomeen. not-yet-due
Not reported 2009-017589-22 Interacties tussen hart en nieren tijdens de behandeling van gedecompenseerd hartfalen: diuretica versus ultrafiltratie (CRUF Trial) 2011-10-21 due-trials
Not reported 2009-017997-19 Influence of oral doxycycline on wound healing after endonasal endoscopic sinus surgery for chronic rhinosinusitis with and without nasal polyposis: a double-blind randomized placebo-controlled trial. 2016-10-06 due-trials
Ongoing 2009-017998-37 Scintigraphic detection of tumor necrosis factor with radioactive labeled TNFα-blocker in patients with active rheumatoid arthritis and active axial and peripheric spondyloarthropathy. not-yet-due
Ongoing 2010-018628-14 Pharmacokinetic evaluation of moxifloxacin administered intravenously and orally in healthy volunteers who have had a gastric bypass. not-yet-due
Not reported 2010-019691-70 Pharmacokinetic evaluation of fluoroquinolone antibiotics administered intravenously in intensive care patients with normal renal function and with renal hyperfiltration 2013-12-01 due-trials
Ongoing 2010-021050-20 Assessment of the optimal dosing of piperacillin-tazobactam in intensive care unit patients: extended versus continuous infusion not-yet-due
Ongoing 2010-022572-32 Invloed van Somatuline® autogel 120mg op post-operatieve drainage na rectumresectie voor rectumcarcinoom not-yet-due
Not reported 2010-023155-28 Dexmedetomidine pharmacokinetics-pharmacodynamics in mechanically ventilated neonates with single-organ respiratory failure (NEODEX) 2016-09-22 due-trials
Completed, but no date 2011-000527-33 Characteristics of adult patients with nocturia and nocturnal polyuria and analysis of pharmacokinetic and –dynamic characteristics of desmopressin Melt in this population bad-data
Completed, but no date 2011-000666-35 Analysis of the effect and side effects of desmopressin melt in patients with nocturnal polyuria. bad-data
Ongoing 2011-000984-29 Prospectieve vergelijkende studie tussen verschillende tumescentie technieken bij endoveneuze ablatie behandeling voor varices not-yet-due
Ongoing 2011-003071-11 Cognitieve en emotionele controle: gelijkenissen en verschillen in neuraal substraat - 11C-Raclopride not-yet-due
Ongoing 2011-003678-97 Exploration of TNF-alpha Blockade with golimumab in the Induction of Clinical Remission in Patients with Early peripheral SpondyloArthritis (SpA) according to ASAS-criteria (‘CRESPA’). not-yet-due
Not reported 2011-003786-14 Heeft het toedienen van ketamine of sevoflurane bij kinderen van 0 tot 14 jaar een meerwaarde tijdens het verwijderen van chirurgische thoraxdrains? 2014-03-30 due-trials
Completed, but no date 2011-004540-22 Desmopressin melt therapy in nocturnal polyuria patients: pharmacokinetic/dynamic study bad-data
Ongoing 2011-004560-29 Desmopressin melt therapy in nocturnal polyuria patients: pharmacodynamic study not-yet-due
Ongoing 2011-004989-16 The effect of morphine and different local anesthetics on human chondrocytes: an in vivo study. not-yet-due
Completed, but no date 2011-006107-35 Pharmacokinetics of small spectcrum beta-lactam antibiotics (Amoxicillin/Clavulanic Acid and Cefuroxime) on intensive care. bad-data
Ongoing 2011-006336-23 The effects of sodium oxybate in patients with chronic fatigue syndrome not-yet-due
Not reported 2012-000701-77 Cytoreduction followed by Normothermic versus Hyperthermic Intraperitoneal Intraoperative Chemoperfusion: a Phase II Study in Peritoneal Carcinomatosis 2013-12-31 due-trials
Not reported 2012-002925-30 The influence of oxytocin on automatic imitation 2013-02-06 due-trials
Completed, report not yet due 2012-002927-14 Dosistitratie van lisinopril bij kinderen van 1 tot 18 jaar met primaire of secundaire hypertensie 2018-06-14 not-yet-due
Ongoing 2012-004490-10 A Multicenter Open label Phase 2 study of Carfilzomib Weekly plus Melphalan and Prednisone in Untreated Symptomatic Elderly Multiple Myeloma. not-yet-due
Not reported 2012-005127-33 Pharmacokinetic and pharmacodynamic evaluation of linezolid administered intravenously in MRSA-positive, morbidly obese patients with pneumonia. 2016-09-30 due-trials
Ongoing 2013-000384-87 Intraperitoneal atomization of levobupivacaine during gynecological laparoscopic procedures : Impact on pain, opioid use and length of recovery room stay (IPLA). not-yet-due
Ongoing 2013-000782-36 Effect of TachoSil® on incidence of symptomatic and radiographic lymphoceles after extended pelvic lymph node dissection in prostate and bladder cancer. not-yet-due
Ongoing 2013-002340-90 Study of the molecular mechanisms underlying the cross-neutralizing capacity of AS04-adjuvanted HPV vaccine (Cervarix®) in comparison with the aluminiumhydroxyphosphate sulphate adjuvanted HPV vaccine... not-yet-due
Completed, report not yet due 2013-002395-40 Prospective intervention trial with adjuvant metformin in girls and boys with classic CAH (METFOR CAH). 2018-02-16 not-yet-due
Completed, but no date 2013-002964-22 Influence of aromatase inhibitors on insulin sensitivity, liver and hart function in obese men bad-data
Ongoing 2013-004191-35 Evaluation of the effects and plasma concentration of the potent platelet inhibitor ticagrelor, after crushed and non-crushed intake, after semi-urgent coronary bypass and in patients after cardiac ar... not-yet-due
Ongoing 2013-004918-18 Optimising adalimumab treatment in psoriasis with concomitant methotrexate. not-yet-due
Ongoing 2013-004953-26 CMV specific T cell therapy for the treatment of relapsing or therapy refractory CMV infection after allogeneic stem cell transplantation with a CMV-positive donor. not-yet-due
Ongoing 2013-005056-15 Longterm efficiency and safety of intravitreal injections with bevacizumab in patients with neovascularisation or macular edema. not-yet-due
Ongoing 2013-005209-30 The effect of Hydroxyethylstarch 6% 130/0.4 in a balanced electrolyte solution (Volulyte®) compared to gelatine (Geloplasma®) on microvascular reactivity and tissue oxygen saturation during haemodilut... not-yet-due
Ongoing 2013-005533-20 Volatile anesthetics to reduce mortality in cardiac surgery. A multicentre randomized controlled study. not-yet-due
Not reported 2014-000882-34 Catheter based adjuvant intraperitoneal chemotherapy for carcinomatosis. 2015-11-13 due-trials
Not reported 2014-001005-41 Evaluation of FLuid REsuscitation with Sterofundin ® ISO (Ringerfundin), Plasma-Lyte® or NaCl 0.9%. (FluReS study) 2016-01-29 due-trials
Ongoing 2014-003141-10 Invloed van UDCA op fecale galzoutensamenstelling van IBD patiënten: piloot studie. not-yet-due
Ongoing 2014-003177-42 Multinational study assessing the acceptability and determinants of compliance to HPV vaccination to women in screening ages 25 to 45 years not-yet-due
Ongoing 2014-003543-35 A clinical study to generate a set of data characterising clinical events, physiological responses, and innate and adaptive immune responses following a single intramuscular immunisation with FluadTM ... not-yet-due
Not reported 2014-004638-24 Pharmacokinetics of ciprofloxacine in pediatric patients, a pilot study – SAFE PEDRUG. 2017-03-17 due-trials
Ongoing 2014-005200-13 study of the pharmacokinetics and pharmacodynamics of desmopressin oral lyophilisate - route of administration in the pediatric patient population - SAFEPEDRUG not-yet-due
Completed, report not yet due 2014-005469-58 Determination of the minimum local anesthetic dose (MLAD) of spinal chloroprocaine for inguinal herniorrhaphy in ambulatory surgery. 2018-01-24 not-yet-due
Ongoing 2015-000418-23 Intraoperative intraperitoneal chemoperfusion to treat peritoneal minimal residual disease in stage III ovarian cancer: a randomized phase II trial. not-yet-due
Not reported 2015-001282-13 Evaluation of acute normovolemic hemodilution on coagulation during liver surgery. 2017-03-24 due-trials
Ongoing 2015-001289-24 99m Tc- sestaMIBI/pertechnetaat SPECT subtractie beeldvorming versus 18F-Fluorocholine PET/CT voor de preoperatieve lokalisatie van hyperfunctionerende parathyroïden bij primaire hyperparathyroidie. not-yet-due
Ongoing 2015-002223-25 Eradication of methicillin-susceptible Staphylococcus aureus nasal carriage in patients undergoing dialysis: can fusidic acid be used as an alternative to mupirocin? not-yet-due
Ongoing 2015-002865-40 Open label two treatment half-side comparative study to analyse difference in nasal bioavailability between MP29-02 and fluticasone propionate. not-yet-due
Completed, but no date 2015-002879-14 BioVacSafe-Boostrix®: een klinische studie om een reeks gegevens te regenereren die kenmerkend zijn voor klinische gebeurtenissen, fysiologische reacties en aangeboren en adaptieve immuunreacties volg... bad-data
Ongoing 2015-003223-53 RANKL-blockade for the treatment of erosive osteoarthritis (OA) of interphalangeal finger joints not-yet-due
Completed, report not yet due 2015-003552-48 Pilot trial to determine the efficacy of secukinumab in active non-segmental vitiligo 2018-01-16 not-yet-due
Not reported 2015-004918-22 A comparison of chloroprocaine 3% versus levobupivacaine 0.5% for epidural anesthesia during caesarean section. 2017-04-04 due-trials
Not reported 2016-000398-19 Pilot study: pharmacokinetics of beta-lactam antibiotics, piperacillin-tazobactam, ceftazidim and meropenem in blood and sputum of cystic fibrosis patients. 2016-08-31 due-trials
Ongoing 2016-001263-37 Phase I trial of stereotactic body radiotherapy with concurrent pembrolizumab in metastatic urothelial cancer. not-yet-due
Ongoing 2016-001569-97 A phase II Investigation of Pembrolizumab (Keytruda) in combination with radiation and an immune modulatory cocktail in patients with cervical and uterine cancer. not-yet-due
Completed, report not yet due 2016-001790-33 A PHASE II, SINGLE-CENTRE, PROSPECTIVE EXPLORATORY TRIAL TO ASSESS THE EFFICACY OF LANREOTIDE AUTOGEL 120 MG IN THE SYMPTOMATIC TREATMENT OF ACUTE RADIATION INDUCED DIARRHEA 2018-07-27 not-yet-due
Ongoing 2016-001839-13 Influence of a bolus administration of ephedrine and phenylephrine on spinal oxygen saturation, measured with NIRS. not-yet-due
Ongoing 2016-002379-89 Treatment of acute locomotoric pain in the geriatric patient: comparison of effectiveness and safety between step 2 (weak opioids) and step 3 (strong opioids) pain relief of the WHO-ladder. not-yet-due
Ongoing 2016-002430-76 Double-blind, randomized, placebo controlled noninferiority intervention study to REduce STEroids in Relapsing Nephrotic syndrome not-yet-due
Ongoing 2016-002878-13 Comparison of continuous infusion versus automated bolus of local anesthetic for postoperative analgesia with popliteal sciatic nerve blockade (nerve catheters) in ambulatory foot surgery. not-yet-due
Ongoing 2016-004300-65 Optimizing the Biologic Treatment Strategy in Rheumatoid Arthritis (RA) Patients that have failed a Tumor Necrosis Factor-alpha (TNFα) blocking Agent by immunoscintigraphy with Technetium-labeled Cimz... not-yet-due
Ongoing 2017-000071-90 Effect of sevoflurane and propofol on hepato-splanchnic pressure and flow during hepatobiliary surgery. not-yet-due
Ongoing 2017-000116-42 A clinical study of biomarkers of innate and adaptive immune activation associated with symptoms and immune responses after administration of a single dose of a quadrivalent inactivated split virus in... not-yet-due
Ongoing 2017-000133-31 Combined hypofractionated stereotactic body radiotherapy with immunomodulating systemic therapy for inoperable recurrent head and neck cancer: detection of the maximum tolerated dose. not-yet-due
Ongoing 2017-001688-20 INTRAPERITONEAL AEROSOLISATION OF ALBUMIN-STABILIZED PACLITAXEL NANOPARTICLES FOR PERITONEAL CARCINOMATOSIS – PHASE I/II STUDY PROTOCOL not-yet-due
Ongoing 2017-001728-23 Efficacy of golimumab in early axial spondyloarthritis (axSpA) in relation to gut inflammation, an early remission induction study (GO GUT). not-yet-due
Ongoing 2017-003278-15 Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass Grafting not-yet-due
Ongoing 2017-003461-96 PSMA-PET/CT for prostate cancer not-yet-due
Ongoing 2017-005059-10 Multicentric, double-blind, placebo controlled clinical trial with 5-hydroxytryptophan (5-HTP) in patients with inflammatory bowel disease in clinical and biologic remission: effect on fatigue scores not-yet-due