These trials completed more than 12 months ago and should have reported results. Some have, some have not.

These trials are not yet due to report results: some are ongoing, some completed within the past 12 months.

These trials have problematic data on the registry. Details why »

Status Trial ID Title Completion date Category
Ongoing 2004-000193-31 Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy not-yet-due
Listed as ongoing, but also has a completion date 2004-001496-20 A randomised phase II pilot trial of carboplatin compared to docetaxel for patients with metastatic genetic breast cancer. 2010-04-01 bad-data
Ongoing 2004-001621-16 An intergroup randomised trial of rituximab versus a watch and wait strategy in patients with advanced stage, asymptomatic, non-bulky fillicular lymphoma not-yet-due
Reported results 2004-001926-26 XERXES: Examining the role of early neoadjuvant and synchronous Erbitux in pre-operative chemo-radiotherapy using Xeloda followed by excisional surgery. A phase I/II dose escalation study of intrave... 2015-11-25 due-trials
Reported results 2004-002197-34 A phase III multicentre randomised clinical trial comparing rituximab with CHOP given every 14 days and rituximab with CHOP given every 21 days for the treatment of patients with newly diagnosed diff... 2017-04-03 due-trials
Completed, report not yet due 2004-003845-41 Transplantation of umbilical cord blood (UCB) from unrelated donors (URD) in patients with haematological diseases using a reduced intensity conditioning regimen. 2020-04-01 not-yet-due
Reported results 2005-000701-61 An open label trial of the dual specificity endothelin receptor antagonist bosentan in established scleroderma renal crisis 2008-04-03 due-trials
Ongoing 2005-001030-33 PATCH not-yet-due
Reported results 2005-001173-96 Porfimer sodium photodynamic therapy plus stenting versus stenting alone in patients with advanced or metastatic cholangiocarcinomas and other biliary tract tumours: a multicentre, randomised, phase l... 2011-07-26 due-trials
Reported results 2005-001949-42 A randomised controlled trial of neuroprotection with lamotrigine in secondary progressive multiple sclerosis 2008-12-29 due-trials
Reported results 2005-002274-30 A Study to assess the safety, efficacy and tolerability of Rituximab(Mabthera) in combination with Plasma Exchange in patients with Acute Thrombotic Thrombocytopenia Purpura. 2010-02-04 due-trials
Reported results 2005-003254-10 A Phase II Study to determine the efficacy and safety of conventional dose oral Treosulfan in patients with advanced pre-treated Ewing’s Sarcoma 2013-05-21 due-trials
Reported results 2005-003479-19 A Phase II Single Arm Study of the use of CODOX-M/IVAC with Rituximab (R-CODOX-M/IVAC) in the treatment of patients with Diffuse Large B-Cell Lymphoma (DLBCL) or Burkitt's Lymphoma (BL) of Internation... 2016-04-02 due-trials
Ongoing 2005-003687-37 HiLo: Multicentre randomised phase III clinical trial of high versus low dose radioiodine, with or without recombinant human thyroid stimulating hormone (rhTSH), for remnant ablation following surgery... not-yet-due
Reported results 2005-003888-23 A phase II multicentre trial of CVP, rituximab and gemcitabine for the treatment of patients with newly diagnosed diffuse large b-cell lymphoma considered unsuitable for r-chop chemotherapy 2011-07-11 due-trials
Reported results 2005-003931-40 Phase ll Trial of Fludarabine & Cyclophosphamide followed by Thalidomide for Angioimmunoblastic Lymphoma 2014-01-08 due-trials
Completed, but no date, and reported results Terminated 2005-005751-18 A multi-centre randomised study to evaluate the efficacy of Betaferon-interferon-beta-1b (IFNB-1B) 500 mcg therapy in the induction of tolerance to IFNB in MS patients with neutralising antibodies (NA... bad-data
Reported results Terminated 2005-005821-71 A multicentre phase III randomised double blind placebo controlled trial of pravastatin added to first-line chemotherapy in patients with small cell lung cancer 2013-11-13 due-trials
Reported results 2006-000113-38 A randomised phase II double blind placebo controlled trial of Whole Brain Radiotherapy (WBRT) and Tarceva (OSI-774, erlotinib) in patients with advanced non-small cell lung cancer (NSCLC) with multip... 2010-11-11 due-trials
Ongoing 2006-000205-34 Radiotherapy and Androgen Deprivation in Combination After Local Surgery. A randomised controlled trial for patients with prostate cancer. not-yet-due
Reported results 2006-000591-33 A Phase II study of Gemcitabine and Bexarotene (GemBex) in the treatment of cutaneous T-cell lymphoma 2014-01-23 due-trials
Reported results 2006-001965-41 Phase III, multicentre, randomised study of fludarabine/cyclophosphamide combination with or without Rituximab in patients with untreated mantle cell lymphoma 2015-04-22 due-trials
Listed as ongoing, but also has a completion date 2006-006079-19 A Phase III Randomised Double-blind Study Comparing Sorafenib With Placebo In Patients With Resected Primary Renal Cell Carcinoma at High or Intermediate Risk of Relapse 2020-03-10 bad-data
Reported results Terminated 2006-006949-13 A multi-centre exploratory study to evaluate the efficacy of the dopamine receptor agonist rotigotine in the treatment of hemispatial neglect and motor deficits following stroke. 2010-09-30 due-trials
Exempt, with results Terminated 2007-001951-20 A phase I and randomised phase II study of Docetaxel and RAD001 (Everolimus) in advanced/recurrent or metastatic squamous cell carcinoma of the head and neck 2011-04-07 not-yet-due
Reported results 2007-003080-45 Phase ll study evaluating the toxicity and efficacy of a modified German Paediatric Hodgkin's Lymphoma protocol (HD95) in young adults (aged 18-30 years) with Hodgkin's Lymphoma 2012-09-19 due-trials
Reported results Terminated 2007-003834-40 THE IMPACT OF REDUCING OVERTREATMENT ON QUALITY OF LIFE IN CHILDREN 2013-05-20 due-trials
Reported results Terminated 2007-004226-25 Low-dose intravenous immunoglobulin or 0.9% saline in the treatment of trigeminal neuralgia refractory to carbamazepine – a randomized double blind parallel placebo-controlled multicentre trial in an ... 2010-06-17 due-trials
Ongoing 2007-006064-30 A randomised phase III trial to assess response adapted therapy using FDG-PET imaging in patients with newly diagnosed, advanced Hodgkin Lymphoma not-yet-due
Reported results 2007-006701-25 EXCITE: Erbitux, Xeloda, Campto, Irradiation Then Excision for locally advanced rectal cancer. (North West Clinical Oncology Group-04 on behalf of the NCRI rectal cancer subgroup) 2016-12-31 due-trials
Exempt, with results 2007-007612-29 Immunotherapy with CD19ζ chimeric antigen receptor gene-modified EBV-specific CTLs after stem cell transplant in children with high-risk acute lymphoblastic leukaemia 2019-03-18 not-yet-due
Reported results Terminated 2007-007639-17 A multicentre, randomised, phase III trial of platinum-based chemotherapy versus non-platinum chemotherapy, after ERCC1 stratification, in patients with advanced/metastatic non-small cell lung cancer 2014-11-04 due-trials
Listed as ongoing, but also has a completion date and reported results 2008-000837-23 A GCIG Intergroup multicentre trial of open label carboplatin and 2015-07-31 bad-data
Reported results 2008-004858-33 Open label pilot study to treat women with chronic urinary retention or voiding dysfunction due to a primary disorder of sphincter relaxation (Fowler’s syndrome) with outpatient urethral sphincter inj... 2012-07-19 due-trials
Reported results Terminated 2008-004955-31 Phase II Study of Reduced Intensity Sibling Allogeneic Transplantation for Relapsed, Chemosensitive, PET Positive Hodgkin Lymphoma. 2012-06-21 due-trials
Not reported 2008-004956-60 Phase II Study of Reduced Intensity Allogeneic Transplantation for Refractory Hodgkin Lymphoma 2019-07-02 due-trials
Ongoing 2008-005073-36 A randomised placebo-controlled, double blinded, phase III trial of sorafenib in combination with transarterial chemoembolisation in hepatocellular cancer. not-yet-due
Reported results 2008-005428-99 A randomised controlled phase III trial comparing hyperthermia plus mitomycin to a second course of bacillus Calmette-Guerin or standard therapy in patients with recurrence of non-muscle invasive blad... 2016-10-07 due-trials
Reported results 2008-005508-14 A phase 3 randomized, placebo-controlled blinded investigation of six weeks vs. six months of oral valgancoclovir therapy in infants with symtomatic congenital cytomegalovirus infection. DMID # 06-004... 2013-05-20 due-trials
Ongoing 2008-005782-59 ARISTOTLE - A phase III trial comparing standard versus novel CRT as pre-operative treatment for MRI defined locally advanced rectal cancer. not-yet-due
Exempt, with results Terminated 2008-006649-18 CMV TCR Gene Therapy: A Phase I Safety, Toxicity and Feasibility Study of Adoptive Immunotherapy with CMV TCR-transduced Donor-derived T cells for Recipients of Allogeneic Haematopoietic Stem Cell Tra... 2018-12-11 not-yet-due
Reported results 2009-009357-22 A phase IV randomised, placebo controlled, double-blind, single centre, out-patient trial to investigate the functional benefit of botulinum toxin injections combined with physiotherapy treatment for ... 2014-04-22 due-trials
Reported results Terminated 2009-010163-16 Bile salt manipulation as a novel treatment for Crohn’s disease: a single centre open label pilot study of atorvastatin and colesevalam in patients with active ileal Crohn’s disease 2012-04-25 due-trials
Reported results Terminated 2009-011818-21 Transplantation of umbilical cord blood from unrelated donors in patients with haematological diseases using a myeloablative conditioning regimen 2015-04-25 due-trials
Reported results 2009-012405-18 Single site, phase II, double blind, randomised, placebo controlled study of the effect of dutasteride (Avodart)0.5 mg on the volume and characteristics of prostate cancer, as assessed by multifunctio... 2013-12-03 due-trials
Ongoing 2009-012717-22 UKALL14 - A randomized trial for adults with newly diagnosed acute lymphoblastic leukemia not-yet-due
Reported results 2009-012968-13 A Proof of Principle, Double-Blind, Randomised Placebo-Controlled,Multi-centre Trial of pravaStatin to Ameliorate Early Onset Pre-eclampsia 2014-09-09 due-trials
Reported results 2009-013408-30 Randomised phase II trial of cediranib (AZD2171) vs. placebo in addition to cisplatin / gemcitabine chemotherapy for patients with advanced biliary tract cancers 2014-09-26 due-trials
Exempt, with results Terminated 2009-013638-26 A phase I/II study of first line Vorinostat with pemetrexed-cisplatin, in patients with malignant pleural mesothelioma 2011-08-22 not-yet-due
Reported results Terminated 2009-014906-33 A Pilot study of Response to Velcade combination chemotherapy in AL amyloidosis (REVEAL) 2014-12-18 due-trials
Reported results 2009-014907-29 A prospective randomised controlled phase III trial of gemcitabine and docetaxel compared with doxorubicin as first line treatment in previously untreated advanced unresectable or metastatic soft tiss... 2019-05-08 due-trials
Reported results 2009-016096-29 Pilot of oral Sildenafil for the treatment of Pulmonary Hypertension in Thalassaemia with comparison to controls. 2010-09-28 due-trials
Reported results 2009-017171-13 A randomised placebo-controlled trial of saracatinib (AZD0530) plus weekly paclitaxel in platinum-resistant ovarian, fallopian tube or primary peritoneal cancer. 2014-01-12 due-trials
Reported results Terminated 2009-017939-18 A Phase 4 randomised, double-blind, placebo controlled, crossover trial Nitrofurantoin Macrocrystals 100 mg twice daily for six weeks in the treatment of overactive bladder symptoms associated with a... 2014-10-20 due-trials
Reported results 2009-018137-37 An open label, single site, 12 month, Phase II, randomised controlled trial evaluating the safety and efficacy of Exendin-4 (Exenatide) in the treatment of patients with moderate severity Parkinson's ... 2013-04-03 due-trials
Reported results 2010-020944-37 Pilot study to establish laboratory methods for urine Nerve Growth Factor (NGF) and immunohistochemical staining of the vanilloid receptor (TRPV1) in bladder biopsies, following open label treatment w... 2015-05-14 due-trials
Not reported 2010-021598-35 Phase II study of Bortezomib, Adriamycin and Dexamethasone (PAD) therapy for previously untreated patients with multiple myeloma: Impact of minimal residual disease (MRD) in patients with deferred ASC... 2019-09-09 due-trials
Ongoing 2010-022209-16 ICON8 Trials Programme not-yet-due
Reported results 2010-022754-17 Bevacizumab And Combination Chemotherapy in rectal cancer Until Surgery: A Phase II, Multicentre, Open-label, Randomised Study of Neoadjuvant Chemotherapy and Bevacizumab in Patients with MRI defined ... 2019-02-14 due-trials
Reported results Terminated 2010-023217-61 A phase IV, open-label, partial cross-over partial parallel, randomized, multi-centre study to compare the gastrointestinal tolerability of once daily oral deferasirox, when administered before or aft... 2012-07-16 due-trials
No trial status on register 2010-023502-12 A Proof of Principle, Double-Blind, Randomised Placebo-Controlled,Multi-centre Trial of pravaStatin to Ameliorate Early Onset Pre-eclampsia bad-data
Reported results 2010-024520-15 A pilot study to establish the safety and efficacy of a combination of dexamethasone and lenalidomide in patients with relapsed or refractory chronic lymphocytic leukaemia (CLL) 2016-02-01 due-trials
Reported results Terminated 2011-000038-12 A Phase 2b randomised, double blind, placebo-controlled trial of trimetazidine therapy in patients with non-obstructive hypertrophic cardiomyopathy. 2015-04-30 due-trials
Ongoing 2011-000144-21 ION– Is ablative radiOiodine Necessary for low risk differentiated thyroid cancer patients not-yet-due
Reported results Terminated 2011-001063-43 A Phase III single-blind, randomised, placebo controlled trial of long term therapy in patients with stable COPD using Moxifloxacin, Azithromycin, and Doxycycline: a Bayesian decision analysis, includ... 2013-07-04 due-trials
Ongoing 2011-001300-35 A phase III multicentre trial of weekly induction chemotherapy followed by standard chemoradiation versus standard chemoradiation alone in patients with locally advanced cervical cancer not-yet-due
Not reported 2011-001836-44 A Phase II Trial to Assess the Activity of TroVax® (MVA-5T4) Versus Placebo in Patients with Relapsed Asymptomatic Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer. 2019-04-19 due-trials
Reported results 2011-003475-11 A phase II double-blind, randomised, placebo-controlled trial of neuroprotection with phenytoin in acute optic neuritis 2014-12-06 due-trials
Reported results 2011-003608-19 Trial of afatinib (BIBW 2992) in suspected or confirmed mutant EGFR lung cancer patients unfit for chemotherapy 2018-11-30 due-trials
Completed, report not yet due Terminated 2011-005156-34 Subcutaneous Bortezomib, Cyclophosphamide and Rituximab (BCR) versus Fludarabine, Cyclophosphamide and Rituximab (FCR) for initial therapy of Waldenstrőm macroglobulinaemia: a randomised phase II stud... 2020-08-02 not-yet-due
Reported results 2011-005814-12 Phase II, randomised, placebo controlled, multicentre, feasibility study of low dose (metronomic) cyclophosphamide with or without nintedanib (BIBF 1120) in advanced ovarian cancer (METRO-BIBF) 2017-10-18 due-trials
Ongoing 2011-005889-38 A UK multicentre phase II study of haploidentical stem cell transplantation in patients with haematological malignancies not-yet-due
Reported results Terminated 2012-000091-41 A randomised phase 2 trial investigating the additional benefit of hydroxychloroquine(HCQ) to short course radiotherapy (SCRT) in patients aged 70 years and older with high grade gliomas (HGG) 2019-07-25 due-trials
Exempt 2012-001598-10 A phase I/II study of first line Ganetespib with pemetrexed/cisplatin, in patients with malignant pleural mesothelioma 2019-11-05 not-yet-due
Ongoing 2012-001900-39 A multicentre randomised phase II clinical trial of Inotuzumab Ozogamicin plus Rituximab and CVP (IO-R-CVP) versus Gemcitabine plus Rituximab and CVP (Gem-R-CVP) for the first line treatment of patien... not-yet-due
Reported results 2012-002345-38 A prospective randomised controlled phase II/III clinical trial of rivaroxaban versus warfarin in patients with thrombotic antiphospholipid syndrome, with or without SLE. 2015-06-08 due-trials
Reported results 2012-002767-95 Long term antibody response to CMV gB vaccine in patients requiring liver or renal transplant. A Phase II open, single-site study, in participants who received CMV gB vaccine or placebo in previous tr... 2016-06-13 due-trials
Reported results 2012-002786-35 A randomised double-blind controlled phase III study to compare the efficacy and safety of intravenous ferric carboxymaltose with placebo in patients with anaemia undergoing major open abdominal surge... 2019-05-10 due-trials
Reported results 2012-002933-12 A Phase II pilot study to explore treatment with Sodium Valproate in Adults with McArdle Disease (Glycogen Storage Disorder Type V, GSDV) 2017-04-05 due-trials
Reported results 2012-003921-13 COMbination therapy for PulmonAry hypertension using RacEcadotril (COMPARE). 2017-04-05 due-trials
Ongoing 2012-005111-12 FOCUS4 – Molecular selection of therapy in colorectal cancer: a molecularly stratified randomised controlled trial programme not-yet-due
Reported results 2012-005394-31 MS-SMART: A Multi-Arm Phase IIb Randomised, Double Blind Placebo-Controlled Clinical Trial Comparing The Efficacy of Three Neuroprotective Drugs in Secondary Progressive Multiple Sclerosis 2018-07-04 due-trials
Reported results Terminated 2013-000361-36 A phase IIa/b, randomised, double-blind, placebo-controlled, single-site, parallel group clinical trial to examine cannabidiol (CBD) as a pharmacological treatment for cannabis dependence in a young c... 2018-06-01 due-trials
Reported results 2013-000750-21 The HALT-LTBI study: Phase IV, multi-site, unblinded, randomised trial of prophylactic daily rifampicin/isoniazid vs. weekly rifapentine/isoniazid for latent tuberculosis infection (LTBI) 2017-05-17 due-trials
Completed, but no date 2013-000872-14 Adoptive Immunotherapy with CD25/71 allodepleted donor T cells to improve immunity after unrelated donor stem cell transplant (ICAT) bad-data
Reported results 2013-000966-12 Autologous Stem Cells in Achilles Tendinopathy (ASCAT)- A phase II, single centre, proof of concept study 2018-09-12 due-trials
Reported results 2013-001069-18 MINeralocorticoid receptor antagonist pretreatment to MINIMISE reperfusion injury after ST-Elevation Myocardial Infarction(STEMI). 2016-04-04 due-trials
Not reported Terminated 2013-001922-24 The effect of remote ischaemic preconditioning and glyceryl trinitrate on peri-operative myocardial injury in cardiac bypass surgery patients (ERIC-GTN study)- a four arm randomised controlled trial 2018-11-12 due-trials
Ongoing 2013-002195-40 A randomised controlled trial of the ketogenic diet in the treatment of epilepsy in children under the age of two years not-yet-due
Reported results 2013-002951-14 Human papillomavirus infection: a randomised controlled trial of Imiquimod cream (5%) versus Podophyllotoxin cream (0.15%), in combination with quadrivalent human papillomavirus or control vaccination... 2018-01-17 due-trials
Reported results 2013-003200-39 A phase II, single centre, randomised, placebo-controlled, 3-part trial to assess the safety, tolerability and efficacy of Zibotentan in patients with renal disease secondary to scleroderma 2017-10-19 due-trials
Reported results 2013-003363-64 A randomised, double blind, placebo controlled, single centre, 60 week trial of Exenatide once weekly for the treatment of moderate severity Parkinson’s disease. 2016-05-12 due-trials
Reported results 2013-003440-22 a phase IV, double-blind randomised placebo-controlled, parallel group multi-site trial of sertraline compared to placebo in patients presenting with depressive symptoms in primary care where treatmen... 2017-12-31 due-trials
Reported results Terminated 2013-003469-32 A Single Arm Phase II trial of BMN 673 for inoperable, advanced endometrial cancer with retrospective PTEN, MSI and MRE11 analysis. 2015-12-09 due-trials
Reported results 2013-003778-29 Combined Multi-Marker Screening and Randomised Patient Treatment with Aspirin for Evidence-based Pre-eclampsia Prevention 2016-11-03 due-trials
Reported results Terminated 2013-004195-36 A randomised, double-blind, placebo-controlled, phase II clinical trial with a cross-over design assessing efficacy of a single dose of bumetamide in reducing focal attack severity in hypokalaemic per... 2017-05-09 due-trials
Exempt Terminated 2013-004359-18 RegenVOX: Phase I/IIa clinical trial of stem cell based tissue engineered partial laryngeal implants in adult patients with end-stage laryngotracheal stenosis with 24 months follow-up 2018-05-25 not-yet-due
Ongoing 2013-004398-28 A phase III double-blind placebo-controlled randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours. not-yet-due
Listed as ongoing, but also has a completion date 2013-004668-71 An Open Label Randomised Controlled Trial of Mycophenolate Mofetil Versus Cyclophosphamide for the Induction of Remission of Childhood Polyarteritis Nodosa 2020-06-26 bad-data
Ongoing 2014-000506-35 Carfilzomib/Cyclophosphamide/Dexamethasone with maintenance carfilzomib in untreated transplant-eligible patients with symptomatic MM to evaluate the benefit of upfront ASCT not-yet-due
Reported results 2014-001101-40 Sclero XIII: A phase II ,double-blind, randomized, placebo-controlled study to investigate pharmacokinetics (PK), safety and efficacy of intravenous factor XIII treatment in patients with systemic scl... 2018-09-06 due-trials
Completed, report not yet due 2014-002300-24 Albumin To prevenT Infection in chronic liveR failurE (ATTIRE) 2019-12-11 not-yet-due
Not reported 2014-002697-37 Single-centre open label exploratory phase IIb pilot study of exogenous oral Melatonin for the treatment of Nocturia in adults with Parkinson’s disease 2018-12-07 due-trials
Reported results 2014-003119-13 Can simvastatin significantly reduce the amount of immunosuppressive medication required by patients with sight threatening uveitis? A phase IIb, single site, randomized, placebo controlled, double bl... 2018-07-20 due-trials
Ongoing 2014-003656-31 Addition of stereotactic body radiotherapy to systemic chemotherapy in locally advanced biliary tract cancers not-yet-due
Reported results Terminated 2014-004077-16 A Phase IV randomised controlled trial of the selective serotonin reuptake inhibitor Sertraline versus Cognitive Behavioural Therapy for anxiety symptoms in people with Generalised Anxiety Disorder (G... 2016-02-08 due-trials
Completed, report not yet due 2015-000222-11 A phase II, randomised, double-blind, placebo- controlled, multi-site, parallel group clinical trial to examine ketamine as a pharmacological treatment for alcohol dependence in an alcohol dependent p... 2020-02-07 not-yet-due
Ongoing 2015-001355-76 Phase III randomised trial of immunomodulatory therapy in high risk solitary bone plasmacytoma not-yet-due
Reported results 2015-002571-24 A Phase IIA Prospective, Single-Centre, Open Label Clinical Trial to Evaluate the Safety, Tolerability and Pharmacodynamic Effects of Ambroxol in Patients with Parkinson Disease: Ambroxol in Disease M... 2018-04-26 due-trials
Ongoing 2015-004170-15 A multicentre, randomised trial comparing combination gemcitabine/carboplatin and hydroxychloroquine versus carboplatin/etoposide therapy alone in small cell lung cancer (SCLC) not-yet-due
Completed, report not yet due 2015-004210-26 A Phase IV double blind multi-site, individually randomised parallel group controlled trial investigating the use of citalopram, sertraline, fluoxetine and mirtazapine in preventing relapse in patient... 2020-03-08 not-yet-due
Ongoing 2015-005543-14 Safety and efficacy of Belimumab After B cell depletion therapy in systemic LUPUS erythematosus not-yet-due
Ongoing 2016-000709-36 Research into Antipsychotic Discontinuation and Reduction (RADAR): A Randomised Controlled Trial not-yet-due
Reported results 2016-000809-36 Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia (CAP): a randomised controlled trial. 2019-05-21 due-trials
Exempt 2016-000925-38 GO-8: Gene therapy for haemophilia A using a novel serotype 8 capsid pseudotyped adeno-associated viral vector encoding Factor VIII-V3 not-yet-due
Ongoing 2016-001460-11 Corneal cross-linking versus standard care in children with keratoconus, a randomised, multicentre, observer-masked trial of efficacy and safety not-yet-due
Reported results 2016-002531-15 A phase II, open label, non-randomised, single centre, clinical trial of ANX776 in Healthy Volunteers and patients with Glaucoma, Age-Related Macular Degeneration, and Optic Neuritis 2018-06-07 due-trials
Ongoing 2016-002766-31 A phase 2, single arm, European multi-center trial evaluating the efficacy of afatinib as first line or later line treatment in advanced chordoma not-yet-due
Ongoing 2016-003284-19 DEpletion of Serum amyloid P component In Alzheimer’s Disease: DESPIAD. Double-blind placebo controlled randomised phase IIb trial of SAP depletion by CPHPC in mild Alzheimer’s disease. not-yet-due
Ongoing 2016-003575-21 A multicentre, 48 week randomised controlled factorial trial of adding maraviroc and/or metformin for hepatic steatosis in HIV-1-infected adults on combination antiretroviral therapy. not-yet-due
Ongoing 2016-004091-21 Nivolumab and ipilimumab treatment in prostate cancer with an immunogenic signature not-yet-due
Ongoing 2017-000161-75 An international phase III randomised study to evaluate the efficacy of maintenance therapy with olaparib and cediranib or olaparib alone in patients with relapsed platinum-sensitive ovarian cancer fo... not-yet-due
Ongoing 2017-000433-30 Phase II Trial of Pembrolizumab and Radiotherapy in Cutaneous T cell lymphoma not-yet-due
Exempt 2017-000852-24 A Phase I/II, Open label, Multicentre, Ascending Single Dose, Safety Study of a Novel Adeno-associated Viral Vector (FLT180a) in Patients With Haemophilia B not-yet-due
Ongoing 2017-001117-86 A phase IV, prospective, randomised single-blind UK multicentre non-inferiority trial of low-dose versus standard dose rituximab for prevention of relapses in acquired TTP not-yet-due
Ongoing 2017-001950-33 Methylphenidate versus placebo for fatigue in advanced cancer (MePFAC) not-yet-due
Ongoing 2017-002329-39 Renal Adjuvant MultiPle Arm Randomised Trial (RAMPART): An international investigator-led phase III multi-arm multi-stage randomised controlled platform trial of adjuvant therapy in patients with rese... not-yet-due
Completed, report not yet due 2017-002407-10 A double-blinded, randomised, placebo-controlled trial of liraglutide 3.0 mg in patients with poor weight-loss and a suboptimal glucagon-like peptide-1 response following bariatric surgery. 2020-06-11 not-yet-due
Ongoing 2017-002544-32 A phase II study of nivolumab monotherapy in patients with relapsed/refractory Hodgkin lymphoma, fit for autologous stem cell transplant, who fail to reach complete metabolic remission after first or ... not-yet-due
Ongoing 2017-003008-30 A double-blind, randomised, placebo-controlled single-site study of high dose simvastatin treatment for secondary progressive multiple sclerosis: impact on vascular perfusion and oxidative damage not-yet-due
Ongoing 2017-003328-56 A phase 3 randomised, double blind, clinical trial investigating the effectiveness of repurposed simvastatin compared to placebo, in secondary progressive multiple sclerosis, in slowing the progressio... not-yet-due
Ongoing 2017-003592-64 A randomised phase II study evaluating the safety and anti-tumour activity of the combination of avelumab and cetuximab relative to avelumab monotherapy in recurrent/metastatic head and neck squamous ... not-yet-due
Ongoing 2017-003636-36 A phase II trial to assess the efficacy and safety profile of pembrolizumab in patients with performance status 2 with recurrent or metastatic squamous cell carcinoma of the head and neck not-yet-due
Ongoing 2017-003792-63 Phase II trial of maintenance pembrolizumab following weekly paclitaxel for recurrent ovarian, fallopian tube or peritoneal cancer not-yet-due
Ongoing 2017-004168-36 A phase II study of pembrolizumab in patients with advanced gynaecological clear cell cancer not-yet-due
Ongoing 2018-001100-11 Defining best Management in Adult Chronic RhinOsinusitis not-yet-due
Ongoing 2018-001735-49 Rivaroxaban versus warfarin for stroke patients with antiphospholipid syndrome, with or without SLE (RISAPS): a randomised, controlled, open-label, phase II/III, non-inferiority trial not-yet-due
Ongoing 2018-001767-23 A phase II trial to investigate the safety and efficacy of rituximab and pembrolizumab in relapsed/refractory Waldenström’s macroglobulinaemia not-yet-due
Ongoing 2018-002227-42 Avelumab in the frontline treatment of advanced classical Hodgkin lymphoma - a window study not-yet-due
Ongoing 2018-002942-35 A Randomised Controlled Trial of Escitalopram and Nortriptyline compared with placebo and standard psychological care for depression in Parkinson’s Disease not-yet-due
Ongoing 2018-003028-35 A randomised, double blind, parallel group, placebo controlled, Phase 3 trial of exenatide once weekly over 2 years as a potential disease modifying treatment for Parkinson's disease. not-yet-due
Exempt 2018-004522-29 Phase Ib/II trial of Histone Deacetylase Inhibitor CXD101 in combination with Programmed Cell Death Protein-1 Inhibitor Pembrolizumab for relapsed or refractory Diffuse Large B-cell Lymphoma not-yet-due
Ongoing 2019-000581-38 ASEPTIC: Primary Antibiotic prophylaxis using co-trimoxazole to prevent SpontanEous bacterial PeritoniTIs in Cirrhosis not-yet-due
Ongoing 2019-001261-33 Randomised phase II/III study of Rituximab and Ibrutinib (RI) versus Dexamethasone, Rituximab and Cyclophosphamide (DRC) as initial therapy for Waldenström's macroglobulinaemia not-yet-due
Ongoing 2019-002592-34 Research to Improve the Detection and Treatment of Latent Tuberculosis Infection: Diagnostics (RID-TB:Dx) not-yet-due
Ongoing 2019-003962-41 Trial of Ondansetron as a Parkinson’s HAllucinations Treatment not-yet-due
Ongoing 2019-004139-21 A randomised prospective open label pilot trial comparing mycophenolate mofetil (MMF) with no immunosuppression in adults with limited cutaneous systemic sclerosis MINIMISE-Pilot (Mycophenolate in lim... not-yet-due
Ongoing 2019-004433-17 Multi-centre, randomised, open-label, blinded endpoint assessed, trial of corticosteroids plus intravenous immunoglobulin (IVIG) and aspirin, versus IVIG and aspirin for prevention of coronary artery ... not-yet-due
Ongoing 2020-000122-26 A Phase IIa, open label, single-site, 48 week randomised controlled trial evaluating the safety and efficacy of Exenatide once-weekly in the treatment of patients with Multiple System Atrophy not-yet-due
Ongoing 2020-001402-38 An international, Bayesian platform adaptive, randomized, placebo-controlled trial assessing the effectiveness of candidate interventions in preventing COVID-19 disease in healthcare workers. not-yet-due
Ongoing 2020-001640-26 A pilot, open label, phase II clinical trial of nebulised recombinant tissue-Plasminogen Activator (rtPA)in patients with COVID-19 ARDS: The Plasminogen Activator COVID-19 ARDS (PACA) trial not-yet-due
Ongoing 2020-001937-11 A single-site, randomised, controlled, parallel design, open-label investigation of an approved nebulised recombinant human DNase enzyme (dornase alfa) to reduce hyperinflammation in hospitalised part... not-yet-due
Ongoing 2020-002106-68 Favipiravir, lopinavir/ritonavir or combination therapy: a randomised, double blind, 2x2 factorial placebo-controlled trial of early antiviral therapy in COVID-19 not-yet-due
Ongoing 2020-002668-29 A Randomised Controlled Trial of plasma exchange with standard of care compared to standard of care alone in the treatment of severe COVID-19 infection (COVIPLEX) not-yet-due