These trials completed more than 12 months ago and should have reported results. Some have, some have not.

These trials are not yet due to report results: some are ongoing, some completed within the past 12 months.

These trials have problematic data on the registry. Details why »

Status Trial ID Title Completion date Category
Listed as ongoing, but also has a completion date and reported results 2004-000478-30 A randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy, safety, and tolerability of bosentan in patients with mildly symptomatic pulmonary arterial hypertension. 2011-02-11 bad-data
Completed, but no date, and reported results 2004-000631-28 Bosentan use in interstitial lung disease (open label). Long-term open-label study in patients with interstitial lung disease associated with systemic sclerosis who completed the protocol AC-052-330/B... bad-data
Listed as ongoing, but also has a completion date and reported results 2004-000632-82 Long term bosentan open label extension of the RAPIDS-2 study in Systemic Sclerosis patients with ischemic digital ulcers 2009-01-26 bad-data
Listed as ongoing, but also has a completion date and reported results 2004-000745-37 Uncontrolled extension trial to protocol AC-052-406 to evaluate the long term effect of bosentan therapy in patient with pulmonary arterial hypertension related to connective tissue disease (TRUST-ext... 2006-09-28 bad-data
Reported results 2004-002453-31 A Phase IIb, multi-center, international, double-blind, randomized, placebo-controlled, parallel-group, dose-finding study for the prevention of cerebral vasospasm after aneurysmal subarachnoid hemorr... 2006-03-20 due-trials
Not reported 2004-004391-36 A multicenter, open-label, single-arm safety study to investigate the effects of chronic TRACLEER® treatment on testicular function in male patients with pulmonary arterial hypertension 2007-02-21 due-trials
Ongoing, reported early 2004-005157-63 An open label, multicenter study to assess the pharmacokinetics, tolerability, and safety of a pediatric formulation of bosentan in children with idiopathic or familial pulmonary arterial hypertension... not-yet-due
Listed as ongoing, but also has a completion date and reported results 2005-001651-37 A phase IV, open label, non comparative, multicenter study to evaluate the long term efficacy and safety and tolerability of oral miglustat as a maintenance after a switch form enzyme replacement ther... 2010-06-22 bad-data
Listed as ongoing, but also has a completion date and reported results 2005-001965-33 Estudio prospectivo, aleatorizado, controlado con placebo, doble-ciego, multicéntrico, en grupos paralelos, para evaluar la eficacia, seguridad y tolerabilidad de bosentan en pacientes con hipertensió... 2007-02-07 bad-data
Listed as ongoing, but also has a completion date and reported results 2005-001967-70 An open-label, long-term, safety, and tolerability extension study using the pediatric formulation of bosentan in the treatment of children with idiopathic or familial pulmonary arterial hypertension ... 2011-10-28 bad-data
Listed as ongoing, but also has a completion date and reported results 2005-002900-40 BENEFIT-OL / Estudio abierto de extensión a largo plazo en pacientes con hipertensión pulmonar tromboembólica crónica (HPTC) inoperable que hayan completado el protocolo AC-052-366/BENEFIT 2009-02-23 bad-data
Listed as ongoing, but also has a completion date 2005-005066-37 COMPASS-1 / Hemodynamic effects of a single dose of sildenafil in symptomatic patients on bosentan treatment for pulmonary arterial hypertension – A multicenter, open-label, non-comparative, prospecti... 2006-11-30 bad-data
Listed as ongoing, but also has a completion date and reported results 2005-005068-97 Effects of combination of bosentan and sildenafil versus sildenafil monotherapy on morbidity and mortality in symptomatic patients with pulmonary arterial hypertension – A multicenter, double - blind,... 2013-12-06 bad-data
Listed as ongoing, but also has a completion date and reported results 2005-006192-13 A randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of the addition of inhaled iloprost in patients with pulmonary arterial hypertension (PAH) receiving oral silde... 2008-07-17 bad-data
Ongoing, reported early 2006-000374-75 Long-term, open-label, multicenter extension study of bosentan in patients with pulmonary hypertension associated with sickle cell disease completing a double-blind ASSET study (AC-052-368 or AC-052-3... not-yet-due
Listed as ongoing, but also has a completion date and reported results 2006-001183-24 Efectos de Bosentan sobre la morbilidad y mortalidad en pacientes con Fibrosis Pulmonar Idiopática- Estudio fase III, multicéntrico, randomizado, de grupos paralelos, doble ciego, controlado con plac... 2010-04-29 bad-data
Ongoing, reported early 2006-002049-35 "Estudio unicéntrico, a doble ciego, aleatorizado y controlado con placebo, cruzado de 2 brazos, para investigar el efecto de miglustat sobre la diferencia de potencial nasal en pacientes con fibrosi... not-yet-due
Listed as ongoing, but also has a completion date and reported results 2006-002907-15 Multicenter, double-blind, randomized, placebo-controlled, parallel-group study to assess the efficacy, safety and tolerability of tezosentan in patients with pre-operative pulmonary hypertension, due... 2008-05-06 bad-data
Listed as ongoing, but also has a completion date and reported results 2007-001741-18 Estudio de extensión abierta en pacientes con Fibrosis Pulmonar Idiopática que hayan completado el protocolo AC-052-321 / BUILD 3 2010-04-16 bad-data
Listed as ongoing, but also has a completion date and reported results 2007-002440-14 A multicenter, double-blind, randomized, placebo-controlled, parallel group, event-driven, Phase III study to assess the effects of ACT-064992 on morbidity and mortality in patients with symptomatic p... 2012-03-15 bad-data
Listed as ongoing, but also has a completion date and reported results 2007-002584-27 A prospective, multi-center, double-blind, randomized, placebo-controlled, parallel-group study to assess the efficacy and safety of clazosentan in reducing vasospasm-related morbidity and all-cause m... 2010-08-02 bad-data
Listed as ongoing, but also has a completion date and reported results 2007-003328-39 A multi-centre, multinational, open-label single-dose acute hemodynamic study followed by a multi-centre, multinational, randomized, double-blind, parallel-group, placebo controlled study to assess th... 2009-06-09 bad-data
Ongoing 2007-003694-27 Long-term, single-arm, open label extension study of the SERAPHIN study to assess the safety and tolerability of ACT 064992 in patients with symptomatic pulmonary arterial hypertension. not-yet-due
Listed as ongoing, but also has a completion date and reported results 2007-005194-56 Estudio multicéntrico de polisomnografía, aleatorizado, a doble ciego y controlado con placebo, de grupos paralelos, con grupo de referencia con tratamiento activo, para evaluar la eficacia y la segu... 2009-10-16 bad-data
Listed as ongoing, but also has a completion date 2007-006453-12 A multi-centre, multinational, open- label study to evaluate the long-term safety, tolerability and efficacy of ACT-293987 (NS-304) in the treatment of pulmonary arterial hypertension in subjects aged... 2017-12-19 bad-data
Reported results 2008-001209-41 A multi-center, double-blind, placebo-controlled, randomized, multiple dose, 2-period cross-over, Phase IIa study to investigate the pharmacodynamics, tolerability and safety, and pharmacokinetics of ... 2009-01-15 due-trials
Listed as ongoing, but also has a completion date and reported results 2008-001443-19 Multicenter, randomized, double-blind, placebo-controlled, Phase IIa study to evaluate the efficacy, safety, and tolerability of ACT-128800, an S1P1 receptor agonist, administered for 6 weeks to subje... 2009-07-31 bad-data
Completed, but no date, and reported results 2008-002352-20 Single center, double-blind, randomized, placebo-controlled, two-period/two-treatment crossover study investigating the effect of miglustat on the nasal potential difference in patients with cystic fi... bad-data
Listed as ongoing, but also has a completion date and reported results 2008-006054-17 A double-blind, randomized, placebo-controlled, multicenter, parallel group study to evaluate the efficacy, safety, and tolerability of macitentan in patients with idiopathic pulmonary fibrosis 2011-05-31 bad-data
Listed as ongoing, but also has a completion date and reported results 2008-006785-29 A prospective, multi-center, double-blind, randomized, placebo-controlled, parallel-group study to assess the efficacy and safety of clazosentan in reducing vasospasm-related morbidity and all-cause ... 2010-10-14 bad-data
Listed as ongoing, but also has a completion date and reported results 2008-006786-92 Estudio multicéntrico, aleatorizado, de grupos paralelos, doble ciego, controlado con placebo, de búsqueda de dosis para evaluar la eficacia, seguridad y tolerabilidad de tres dosis de ACT-128800, un ... 2011-06-17 bad-data
Not reported 2008-007653-12 Determination of ( 11 C) miglustat uptake in bone tissue and brain using Positron Emission Tomography (PET). 2009-10-06 due-trials
Reported results 2009-010703-80 A Multicenter, Double-blind, Randomized, Placebo-controlled, Crossover Study to Assess the Effects of a Single Dose of Iloprost Power 15 on Exercise Capacity in Patients with Symptomatic Pulmonary Ar... 2009-08-31 due-trials
Completed, but no date, and reported results 2009-011013-24 A Multicenter, Double-blind, Randomized Study comparing the Safety and Tolerability of Iloprost inhalation solution delivered by I-neb utilizing Power disc-15 and Power disc-6 in Patients with Symptom... bad-data
Ongoing 2009-011470-15 Estudio de extensión del estudio AC-058B201, multicéntrico, aleatorizado, de grupos paralelos, doble ciego, para evaluar la seguridad, tolerabilidad, y eficacia a largo plazo de 10, 20, y 40 mg/día ... not-yet-due
Reported results 2009-011975-60 A multi-center, double-blind, placebo-controlled, parallel-group study to establish proof-of-concept and explore the efficacy of different doses of ACT-129968 in adult patients with partly controlled ... 2012-01-12 due-trials
Ongoing, reported early 2009-012450-20 Multicenter, open-label, non-comparative, proof-of-concept, phase 2a study to evaluate the effect of a single infusion of tezosentan on pulmonary vascular resistance in patients with stable, chronic p... not-yet-due
Reported results 2009-014490-41 A multicenter, double-blind, placebo-controlled Phase 3 study assessing the safety and efficacy of selexipag on morbidity and mortality in patients with pulmonary arterial hypertension 2014-04-27 due-trials
Ongoing 2009-014992-31 Estudio de extensión abierta, de grupo único de tratamiento y a largo plazo, para evaluar la seguridad y tolerabilidad de ACT-293987 en pacientes con hipertensión arterial pulmonar not-yet-due
Ongoing 2009-015602-18 Diabetes and vascular complications: the role of endothelin and physical inactivity’ not-yet-due
Reported results 2010-018320-10 An open-label extension of study AC-066A301 investigating the safety and tolerability of ACT-385781A in patients with pulmonary arterial hypertension (PAH) 2015-06-24 due-trials
Listed as ongoing, but also has a completion date and reported results 2010-018322-40 A Multicenter, Single-arm, Open-label, Phase 3b Study to Assess the Effects of Switching From Flolan® to ACT-385781A in Patients with Pulmonary Arterial Hypertension 2012-02-02 bad-data
Listed as ongoing, but also has a completion date and reported results 2010-019283-36 A multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy, safety and tolerability of two doses of ACT-128800, an oral S1P1 receptor agonist, administe... 2012-10-24 bad-data
Listed as ongoing, but also has a completion date and reported results 2010-020941-29 A multi-center, double-blind, randomized, active reference, parallel group study to evaluate the efficacy, safety and tolerability of a 10-day twice daily oral administration of 3 doses of ACT-179811 ... 2012-11-12 bad-data
Listed as ongoing, but also has a completion date and reported results 2010-021793-12 A prospective, multicenter, open-label extension of FUTURE 3 to assess the safety, tolerability and efficacy of the pediatric formulation of bosentan two versus three times a day in children with pul... 2014-08-13 bad-data
Listed as ongoing, but also has a completion date and reported results 2010-021825-11 An open label, prospective multicenter study to assess the pharmacokinetics, tolerability, safety and efficacy of the pediatric formulation of bosentan two versus three times a day in children with pu... 2013-08-26 bad-data
Reported results 2010-022710-77 Prospective, randomized, placebo-controlled, double-blind, multicenter, parallel group study to assess the efficacy, safety and tolerability of macitentan in patients with ischemic digital ulcers asso... 2013-11-29 due-trials
Listed as ongoing, but also has a completion date and reported results 2010-022969-95 Prospective, randomized, placebo-controlled, double-blind, multicenter, parallel group study to assess the efficacy, safety and tolerability of macitentan in patients with ischemic digital ulcers asso... 2014-02-06 bad-data
Ongoing, reported early 2010-023908-27 Effects of bosentan in a HOMogenEous population of SSc subjects with a predefined restriction of blood flow in the hands (HOME) not-yet-due
Ongoing 2010-024211-13 Long term, single-arm, open-label extension study of the MUSIC study to assess the safety and tolerability of macitentan in patients with idiopathic pulmonary fibrosis not-yet-due
Listed as ongoing, but also has a completion date and reported results 2011-000203-41 Multicenter, double-blind, placebo-controlled, randomized, prospective study of bosentan as adjunctive therapy to inhaled nitric oxide in the management of persistent pulmonary hypertension of the new... 2014-01-27 bad-data
Ongoing, reported early 2011-003310-17 "Estudio fase II, multicentrico, doble ciego, randomizado, controlado con placebo para evaluar los efectos de IIoprost inhalado en una prueba de resistencia durante un test de ejercicio cardiopulmonar... not-yet-due
Ongoing, reported early 2011-004106-16 A randomized, prospective, double-blind, placebo-controlled, group sequential multicenter study to assess efficacy, safety, and tolerability of the pediatric formulation of bosentan in children with p... not-yet-due
Ongoing, reported early 2011-004612-31 A prospective, multicenter, non-comparative, open label extension of the FUTURE 5 study to assess safety and tolerability of the pediatric formulation of bosentan in children with pulmonary arterial h... not-yet-due
Not reported 2011-005303-32 Effects of bosentan in a HOMogenEous population of SSc subjects with an early or active SSc nailfold capillaroscopic pattern (HOME II) 2014-06-03 due-trials
Ongoing 2012-000540-10 Multicenter, randomized, double-blind, parallel-group, active-controlled, superiority study to compare the efficacy and safety of ponesimod to teriflunomide in subjects with relapsing multiple scleros... not-yet-due
Ongoing 2012-000541-12 Multicenter, randomized, double-blind, parallel-group, add-on, superiority study to compare the efficacy and safety of ponesimod to placebo in subjects with active relapsing multiple sclerosis who are... not-yet-due
Listed as ongoing, but also has a completion date and reported results 2012-001829-27 Multi-center non-drug-interventional extension study to assess long-term safety and effects on growth in patients who received bosentan or placebo as adjunctive therapy to inhaled nitric oxide for per... 2014-12-05 bad-data
Listed as ongoing, but also has a completion date and reported results 2012-003335-33 A multi-center, double-blind, randomized, placebo-controlled, parallel-group, Phase 3 study to evaluate the effects of macitentan on exercise capacity in subjects with Eisenmenger Syndrome. 2016-12-01 bad-data
Listed as ongoing, but also has a completion date and reported results 2012-004411-31 Long term, single-arm, open-label extension study of protocol AC-055-305 to assess the safety, tolerability and efficacy of macitentan in subjects with Eisenmenger Syndrome 2018-01-12 bad-data
Reported results 2013-002508-15 A multi-center, randomized, double-blind study to compare the efficacy and safety of cadazolid versus vancomycin in subjects with Clostridium difficile-associated diarrhea (CDAD) 2017-06-02 due-trials
Reported results 2013-002528-17 A multi-center, randomized, double-blind study to compare the efficacy and safety of cadazolid versus vancomycin in subjects with Clostridium difficile-associated diarrhea (CDAD) 2017-03-24 due-trials
Reported results 2013-002950-56 Prospective, randomized, placebo-controlled, double-blind, multicenter, parallel-group, 24-week study to assess the efficacy, safety and tolerability of macitentan in subjects with inoperable chronic ... 2016-09-28 due-trials
Ongoing 2013-003457-25 Long term, multicenter, single-arm, open-label extension study of the MERIT-1 study, to assess the safety, tolerability and efficacy of macitentan in subjects with inoperable chronic thromboembolic pu... not-yet-due
Reported results 2013-003462-14 A multi-center, open-label, single-arm, Phase 3b study of macitentan in patients with pulmonary arterial hypertension to psychometrically validate the French, Italian and Spanish versions of the PAH-S... 2015-09-09 due-trials
Ongoing 2013-003489-15 An extension of AC-055-310, a multi-center, open-label, single-arm, Phase 3b study of macitentan in patients with pulmonary arterial hypertension to psychometrically validate the French, Italian and S... not-yet-due
Reported results 2013-003822-96 A prospective, multicenter, double-blind, randomized, placebo-controlled, parallel group, 12-week study to evaluate the safety and tolerability of macitentan in subjects with combined pre- and post-ca... 2015-11-15 due-trials
Reported results 2014-000865-34 A multi-center, double-blind, randomized, placebo-controlled, parallel group, exploratory Phase 2 study to assess efficacy and safety of selexipag in adult subjects with Raynaud's Phenomenon secondary... 2015-06-07 due-trials
Reported results 2014-002984-14 A multicenter, randomized, double-blind, placebo-controlled, dose-response study to investigate the biological activity, safety, tolerability, and pharmacokinetics of ACT-334441 in subjects with syste... 2017-02-28 due-trials
Ongoing 2014-004066-20 A prospective, multicenter, single-arm, open-label, phase 4 study to evaluate the effects of macitentan on Right vEntricular remodeling in Pulmonary ArterIal hypeRtension assessed by cardiac magnetic ... not-yet-due
Ongoing 2014-004624-21 A randomized, double-blind, placebo-controlled, prospective, multicenter, parallel group study to assess the safety and efficacy of macitentan in patients with portopulmonary hypertension not-yet-due
Completed, but no date, and reported results 2015-002721-18 A prospective, multi-center, open-label, single-arm, Phase 2 study to assess the efficacy and safety of clazosentan in reversing angiographically-confirmed cerebral vasospasm in adult subjects with an... bad-data
Ongoing 2015-003438-28 The efficacy and safety of initial triple versus initial dual oral combination therapy in patients with newly diagnosed pulmonary arterial hypertension: A multi-center, double-blind, placebo-controlle... not-yet-due
Listed as ongoing, but also has a completion date 2015-004805-17 A prospective, multicenter study to investigate the pharmacokinetics, safety, and efficacy of cadazolid versus vancomycin in pediatric subjects with Clostridium difficile-associated diarrhea. 2018-04-17 bad-data
Reported results 2016-000826-21 Multi-center, double-blind, randomized, placebo-controlled, active reference, parallel-group, polysomnography dose response study to assess the efficacy and safety of ACT-541468 in adult subjects with... 2017-06-20 due-trials
Reported results 2016-000827-16 Multi-center, double-blind, randomized, placebo-controlled, 5-period, 5-treatment crossover, polysomnography dose-response study to assess the efficacy and safety of ACT-541468 in elderly subjects wit... 2017-06-29 due-trials
Other 2016-001062-28 A multicenter, open-label, randomized, event-driven study to assess efficacy, safety and pharmacokinetics of macitentan versus standard of care in children with pulmonary arterial hypertension not-yet-due
Ongoing 2016-003320-23 Prospective, multi-center, double-blind, randomized, placebo-controlled, parallel-group study assessing the efficacy and safety of macitentan in Fontan-palliated adult and adolescent subjects. not-yet-due
Ongoing 2016-003653-15 A multi-center, double-blind, placebo-controlled Phase 2b study to evaluate the efficacy and safety of macitentan in subjects with heart failure with preserved ejection fraction and pulmonary vascular... not-yet-due
Reported results 2016-004259-59 Multi-center, single-arm, open-label study in patients with Insomnia Disorder to validate the Insomnia Daytime Symptoms and Impacts Questionnaire™ (IDSIQ™) 2017-06-12 due-trials
Ongoing 2016-004719-10 Multicenter, non-comparative extension to study AC-058B301, to investigate the long-term safety, tolerability, and control of disease of ponesimod 20 mg in subjects with relapsing multiple sclerosis not-yet-due
Ongoing 2017-000216-42 A multi-center, double-blind, placebo-controlled, Phase 3b study in patients with pulmonary arterial hypertension to assess the effect of selexipag on daily life physical activity and patient’s self-r... not-yet-due
Other 2018-000145-39 A prospective, multicenter, open-label, single-arm, Phase 2 study to investigate the safety, tolerability and pharmacokinetics of selexipag in children with pulmonary arterial hypertension not-yet-due